7

Synergistic Peptides

100%

Bone Support

15+

Years of Peptide Innovation

More than 15 Years of Peptide Innovation

At Panacea Bio Chem, we are dedicated to advancing peptide research and development, delivering high-quality, custom-made peptides with unparalleled purity and potency.


About Panacea Bio Chem


Founded on a passion for peptide science, Panacea Bio Chem specializes in synthesizing custom amino acid chains, providing an extensive range of peptides tailored to meet diverse research and therapeutic needs. Our state-of-the-art laboratory operates under the strictest conditions, utilizing advanced technologies to ensure the highest quality products.


The VANA Machine

Innovation is at the heart of Panacea Bio Chem, exemplified by our revolutionary VANA (Vacuum Aspiration Needle Assembly) machine. Developed by our Laboratory Director, Bogdan Dicoias, VANA is a unique dual-chamber cartridge filling apparatus that enables us to seal the lyophilized peptide powder chamber under complete vacuum and the bacteriostatic water chamber without introducing any air bubbles. This groundbreaking technology ensures unparalleled sterility, stability, and ease of use in peptide reconstitution, setting us apart in the industry.

Bogdan Dicoias, the visionary behind Panacea Bio Chem, is an AAC (Amino Acid Chain) designer with extensive expertise in peptide research and application. Renowned for his innovative contributions, Bogdan introduced the use of radio frequencies and ultrasound technologies in peptide synthesizing and lyophilization processes, revolutionizing the industry. His cutting-edge developments, including the groundbreaking VANA machine, have solidified Panacea Bio Chem as a leader in peptide science and innovation.

For more information about our products and innovations, visit Panacea Bio Chem.

The Science Behind OsteoREGEN™ – Precision Peptide Formulation

The formulation of OsteoREGEN™ represents a breakthrough in peptide science, combining six synergistic peptides: Thymosin Beta-4 (1.5 mg), BPC-157 (2.5 mg), CJC-1295 without DAC (2 mg), Ipamorelin (3 mg), Calcitonin Salmon (0.1 mg), Teriparatide (0.1 mg), and GHK-Cu (1 mg). Each peptide is carefully prepared, stabilized, and combined through a proprietary multi-step lyophilization  process to ensure maximum efficacy, stability, and controlled release.

Peptide Roles in OsteoREGEN™

  • Thymosin Beta-4: Accelerates wound healing and promotes angiogenesis, ensuring the fracture site receives vital nutrients for recovery.
  • BPC-157: Enhances collagen synthesis, supports soft tissue repair, and reinforces ligament and tendon healing.
  • CJC-1295 without DAC: Stimulates the release of growth hormone, enhancing IGF-1 production for bone density and regeneration.
  • Ipamorelin: A potent growth hormone secretagogue that complements CJC-1295 by promoting bone growth and tissue repair.
  • Calcitonin Salmon: Regulates calcium homeostasis, supporting bone remodeling and fracture healing.
  • Teriparatide: A fragment of parathyroid hormone that directly stimulates bone formation and improves bone density.
  • GHK-Cu: A copper peptide that stimulates the synthesis of collagen, elastin, and glycosaminoglycans, promoting skin and bone repair.

A Precise Multi-Stage Lyophilization Process

The formulation process is highly scientific and intricate, as peptides cannot simply be mixed “like a soup.” Each peptide has unique chemical properties, stability thresholds, and interactions that must be meticulously controlled. Here’s how we ensure the integrity and efficacy of OsteoREGEN™:

Stage 1: Pre-Treatment of Peptides

  1. Stabilization of Peptides: Each peptide is stabilized with specific cryoprotectants such as mannitol, which prevent aggregation and maintain structural integrity during freezing.
  2. pH Optimization: The pH of each peptide solution is adjusted individually to its optimal stability range (e.g., slightly acidic for GHK-Cu to prevent ion imbalance).
  3. Avoiding Oxidation: For peptides like BPC-157 and Thymosin Beta-4, an inert gas (e.g., nitrogen) is used to displace oxygen and prevent oxidative degradation.

Stage 2: First Lyophilization

The initial mixture, excluding GHK-Cu, is frozen rapidly at -80°C to preserve molecular structure. This mix undergoes primary lyophilization in a vacuum, where sublimation removes water without exposing peptides to damaging heat.

Stage 3: Incorporation of GHK-Cu

GHK-Cu is added to the frozen matrix after the first lyophilization stage. This step is critical because lyophilizing GHK-Cu alongside other peptides would allow its ionic copper to interact with and potentially degrade sensitive peptide bonds in the mix. By introducing GHK-Cu at this stage, we maintain the structural integrity of the entire formulation.

Stage 4: Secondary Lyophilization

Once GHK-Cu is integrated, the second lyophilization phase is initiated. This ensures a homogenous, stable product ready for storage and reconstitution.

Ensuring Stability and Controlled Release

  1. Molecular Encapsulation: To ensure slow or fast release as needed, peptides are encapsulated with cyclodextrins or similar carriers, shielding them from enzymatic degradation.
  2. Layered Lyophilization: Peptides with different stability profiles are lyophilized in separate layers within the same cartridge, creating a time-released delivery mechanism upon reconstitution.
  3. Custom Freeze-Drying Cycles: Precise control of shelf temperature, chamber pressure, and drying time ensures optimal stability for each peptide.

A Synergistic Final Mix

When reconstituted with bacteriostatic water, the peptides form a stable and synergistic solution. The carefully balanced mix avoids any detrimental interactions, providing a powerful, targeted approach to bone healing and regeneration. The reconstitution process releases the full therapeutic potential of OsteoREGEN™, making it the ultimate choice for skeletal health and recovery.

We deliver cutting-edge solutions for bone health and regeneration, combining advanced science with unparalleled care to improve lives.

  Benefits From OsteoREGEN™ 

Supports Heart Health

OsteoREGEN™ aids in cardiovascular health by promoting angiogenesis (the formation of new blood vessels), improving circulation, and  reducing inflammation in cardiac tissues.

Strengthens Bone and Skeletal System

Its primary focus remains unparalleled support for bone regeneration, enhancing bone density, accelerating fracture healing, and preventing degenerative conditions.

Boosts Neurological Repair

With peptides like BPC-157, OsteoREGEN™ supports nerve regeneration, reduces inflammation in neural tissues, and may assist in the recovery of peripheral nerve injuries.

Enhances Overall Health and Recovery

The synergistic peptide formulation promotes systemic repair, reduces inflammation, and supports wound healing, improving overall wellness and recovery from injuries.

Protects Eye Health

OsteoREGEN™ may aid in maintaining healthy retinal function, reducing inflammation, and supporting the repair of microvascular structures in the eyes.

Improves Lung Function

By reducing systemic inflammation and supporting tissue repair, OsteoREGEN™ contributes to lung health and recovery from conditions affecting the respiratory system.

Peptourbillon™

At Panacea Bio Chem, under the visionary leadership of Bogdan Dicoias, we introduced the groundbreaking Peptourbillon™ concept. This revolutionary approach embodies the intricate balance of precision and complexity required to design peptide mixes like OsteoREGEN™. Peptourbillon represents the meticulous craftsmanship behind our formulations, simplifying the traditionally complex process of combining multiple peptides into a single, efficient, and stable injectable solution.

The Problem: Complexity in Peptide Formulations

Peptides are highly sensitive biomolecules with specific stability requirements. Combining multiple peptides into a single formulation is not as simple as mixing ingredients in a "soup." Each peptide has:

  1. Unique Stability Ranges: Variations in pH, temperature sensitivity, and solubility can cause peptides to degrade when mixed improperly.
  2. Chemical Interactions: Certain peptides can oxidize, denature, or bind to others, rendering them inactive or even harmful.
  3. Different Therapeutic Targets: Peptides often require distinct release mechanisms to ensure efficacy without interference.

Our Solution: The Peptourbillon™ Approach

The Peptourbillon concept tackles these challenges with a science-driven, multi-step process that ensures:

  1. Chemical Stability: Each peptide is pre-treated to stabilize its structure, avoiding interactions during the formulation process.
  2. Controlled Release: Advanced techniques allow us to design peptides with tailored release profiles, ensuring they function optimally when delivered.
  3. Unified Delivery: The Peptourbillon system simplifies the administration of multiple peptides by delivering them in a single, pre-mixed dose, saving time and reducing the risk of errors.

Key Innovations Behind Peptourbillon™

  1. Individualized Stabilization
    Each peptide in the mix is treated with unique excipients (e.g., mannitol, trehalose) and optimized for its specific pH and temperature requirements. For example:

    • GHK-Cu is stabilized separately to avoid ionic interactions with other peptides.
    • Oxidation-sensitive peptides, like BPC-157, are prepared under inert conditions with nitrogen or argon to prevent degradation.

  2. Sequential Lyophilization
    Peptides are not lyophilized together to prevent adverse interactions:

    • The primary peptides (e.g., TB-500, BPC-157, CJC-1295) undergo a first-stage lyophilization process.
    • GHK-Cu is added after the initial freeze to avoid its copper ions destabilizing the other peptides.
    • The final formulation is then lyophilized in a secondary phase, ensuring a uniform, stable product.

  3. Encapsulation for Stability and Release Control
    Some peptides are encapsulated using cyclodextrins or lipid nanoparticles, which:

    • Protect peptides from degradation during storage and administration.
    • Enable slow or targeted release in the body.

  4. Precision Blending and Vacuum Sealing
    The final mixture is prepared using our proprietary VANA machine. This process ensures:

    • Peptides are blended in a vacuum-sealed environment, maintaining sterility and stability.
    • Complete removal of contaminants and air that could degrade the peptides.

Simplifying a Complex Process

Traditionally, administering multiple peptides requires separate injections, reconstitution, and careful timing. The Peptourbillon™ system revolutionizes this:

The Future of Peptide Science

Peptourbillon is not just a concept; it is a philosophy that reflects our commitment to advancing peptide science. By simplifying complex formulations into efficient solutions, Panacea Bio Chem empowers researchers, clinicians, and patients to unlock the full potential of peptides. With innovations like OsteoREGEN™, Peptourbillon sets a new standard for therapeutic precision and efficacy.


Panacea Peptourbillon™ Compounds

  1. AntiHEDON-X™
    Reduces cravings for alcohol, food, nicotine, and drugs. Promotes healthier habits and self-control.

  2. CelluREVIT™
    Promotes healing, tissue regeneration, and anti-inflammatory effects. Supports muscle repair and enhances collagen synthesis.

  3. BENATICS™
    Optimizes metabolism, supports immune function, and promotes cellular longevity. Enhances mitochondrial function and overall vitality.

  4. HealCONEX™
    Regenerates muscles, tendons, ligaments, and gut tissue. Comprehensive recovery solution for injuries and post-surgical healing.

  5. ExADIPO™
    Manages and reduces weight effectively. Sustained weight loss and improved body composition.

  6. MyoGENTIS™
    Supports tissue repair, angiogenesis, and myogenesis. Enhances muscle growth and recovery after intense physical activity.

  7. AnaboliMORPH™
    Accelerates muscle growth, reduces fat, and enhances recovery. Ideal for overcoming muscle-building plateaus.

  8. TelomeREGEN™
    Enhances telomerase activity and telomere elongation. Promotes cellular rejuvenation and longevity.

  9. EroSOLACE™
    Treats erectile dysfunction and low libido in men and women. Enhances intimate experiences and satisfaction.

  10. OsteoREGEN™
    Accelerates bone healing and regeneration. Supports bone density and recovery from fractures or bone-related conditions.

  11. ClariSOLACE™
    Combines Semax and Selank to enhance cognitive performance, emotional stability, and self-awareness. Improves focus and reduces stress.

  12. AnaboShield™
    Steroid cycle protection. Prevents hair loss, skin spots, kidney damage, and heart damage during steroid use.

  13. GluCONTROL™
    Helps regulate glucose levels, supporting metabolic health and diabetes management.

  14. GonadoTROPINEX™
    Combines gonadorelin with Semax and Selank to stimulate natural testosterone production, enhance mood, and support hormonal health.

 

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